INCOZEN offers full range of in vivo and in vitro pharmacokinetic studies of investigational drugs and drug metabolites in rodents and non-rodents to help lead selection and optimization.

DMPK - In vitro

Metabolic stability in Liver microsomes /S9 fractions (Human, Mouse, Rat, Dog, Monkey)
Permeability - PAMPA
Protein binding assay
CYP Inhibition assay ( liver microsomes)

DMPK - In Vivo

Single and multiple dose PK (rodents and non-rodents)
                        - Routes of administration IP, IV, PO, SC etc
                        - Rats, Mice, Guinea Pigs, Rabbits and Beagle Dogs

Analytical Services

Pre-formulation development
Chemical Stability in relevant buffers and plasma
Solubility studies
Dose formulation analysis
Bio-analysis of active moieties in different matrices (HPLC and LC-MS/MS)