INCOZEN offers Non-GLP Pharmacological testing of drug / metabolites and establishment of PK/PD correlation estimating relevant biomarkers and effective drug/metabolite(s) concentrations. 

In Vitro

Human whole blood and PBMC assays

Cell based Assays using Fluorimetry, Absorbance, Luminescence

Enzyme based Assays

Screening across a 45 cancer cell line panel (Leukemia, Lymphoma, Lung, Gastric, Colon, Glioblastoma, Breast, Ovarian, Hepatic, Prostate)

Molecular Cloning

Transient and Stable cell line development

Cell proliferation/ Cytotoxicity Assays

Gene and Protein expression studies

In Vivo (Inflammation / Immunological Models)

Collagen Induce Arthritis (CIA) in Rat

LPS Induced neutrophilia in Rat

LPS Induced TNF alpha in Rat

Carrageenan Induced Paw edema

Delayed type Hypersensitivity in Mice

TNCB induced contact hypersensitivity in Mice

Concanavalin A induced hepatitis in Mice

OVA induced airway inflammation in Mice/Guinea Pig